National Perspective

Organ Donation: The National Perspective

Organ Procurement Organizations

The fifty-six Organ Procurement Organizations (OPOs) serving the nation represent a unique aspect of the health care system. These community-based, non-profit organizations, including Gift of Life Michigan, are designated by the federal government to recover organs from deceased donors for transplantation. They are the only organizations charged with such a responsibility. Since the creation of the OPO structure in the mid-1980s, the United States has developed one of the most successful systems of donor identification, authorization, recovery and coordination in the world.

The work of OPOs also includes support services for donor families, the clinical management of deceased donors, in-service and professional education of hospital staff, public education and donor registration, tissue donation and the recovery of non-transplantable organs and tissues for medical research.

OPOs are critical to the system that tens of thousands of patients depend upon each year to provide life-saving organ transplants. For this reason, it is important to recognize the ongoing, high-level performance of our donation system and to continue to advocate for system changes that support continuous improvement.

A High-Functioning System

Over the past six years, Organ Procurement Organizations increased annual organ donation by 44% in the United States, a sure sign of a well-functioning donation system continually improving.

US deceased donors chart 2013-2019

During this same time, organ transplants increased substantially, and the number of deaths on the national transplant list trended downward. OPOs commit to maximizing every possible donation opportunity by obtaining authorization for donation, managing the donor, facilitating the organ recovery, and transporting organs to transplant centers.

Wait list removal reasons chart

Moreover, recent data in the Journal of the American Medical Association indicates the performance of the U.S. organ procurement system is among the very best in the world, with 43 of the 50 top-performing international jurisdictions – and 9 of the top 10 performers – being U.S. states. Comparing U.S. and Europe data from the Global Observatory on Donation and Transplantation and UNOS demonstrates again the strong performance of the U.S. OPO and transplant system.

US and Europe organ donation comparison chart

Taken together, the data demonstrates great strengths within the current structure of regionally based Organ Procurement Organizations with close cooperative ties to their area transplant centers and donor hospitals.

Donation Continues During a Public Health Crisis

The effectiveness of the Organ Procurement Organization system is highlighted most recently during the COVID-19 crisis when OPOs – like many other parts of the health care system –  faced  a multitude of complicating factors that made their work significantly more challenging. Despite more restrictive access to hospital ICUs, fewer in-person meetings with donor families and many other hurdles, the OPO community maintained its world leadership. In fact, where as some nations’ deceased donation cases were cut by upwards of 90%, the United States OPO system experienced a short-term reduction in organ donors of approximately 38% and rebounded quickly to pre-COVID levels.

During a different kind of health crisis, that of the ongoing opioid overdose epidemic, OPOs quickly identified the public health implications and worked to create clear clinical pathways for these potential donors and to make the transplant system more open to the use of organs from these donors. As a result, over the last five years, over 6,500 families of overdose victims were able to find solace in donation, and nearly 21,400 transplant recipients received the gift of life. While an increase in donors from overdose was partially responsible for the recent year-over-year increases in donation, it is important to note that non-overdose death donation rates also increased.

Deaths by drug overdose vs non overdose chart

Meeting the Challenge Ahead

With so many patients still awaiting transplant, it is incumbent upon the key stakeholders within the donation and transplant community to work together to align our processes of continual improvement and adopt those measures that will result in more donation opportunities, additional life-saving transplants and better transplant outcomes. Among the most important are:

Adopt More Accurate and Useful OPO Performance Metrics: Organ Procurement Organization leadership and other donation and transplant advocates are calling upon the U.S. Department of Health and Human Services to develop more meaningful, independently reported metrics to accurately reflect the performance of OPOs and appropriately adjust for such critical factors as age, cause of death and extenuating circumstances (such as the COVID-19 pandemic). Improved metrics must also be timely and granular enough to inform and promote continuous improvement and increased donation. The new metrics should be free from known data integrity issues, such as those that plague datasets dependent on death certificates.

Promote the Use of Organs from Older and More Complex Donors: Each year, thousands of organs are authorized and recovered by OPOs that are not considered suitable for transplant by current U.S. surgical practice. However, many of these organs are considered suitable for transplant by other nations’ health care systems. Better aligned regulatory incentives across the OPO and transplant system would result in higher use of organs from Donation after Circulatory Death donors, donors of advanced age and donors with more complex co-morbidities.

Expanded Use of Ex Vivo Perfusion and Preservation: Medical advancement in the perfusion, transport and preservation of donor organs have made it possible to expand the pool of donors from which a successful organ recovery and transplant can be made. Working together, transplant centers, OPOs and regulators can continue adoption of these devices and dramatically improve the function of certain donated organs, leading to more and better transplant outcomes.

Certifications and Accreditations
  • American Association of Tissue Banks
  • Organ Donation and Transplantation Alliance
  • Association of Organ Procurement Organizations
  • College of American Pathologists
  • Clinical Laboratory Improvement Amendments
  • Centers for Medicare & Medicaid Services
  • The American Society for Histocompatibility and Immunogenetics (ASHI)
  • Association of Organ Procurement Organizations
  • Donate Life America
  • Association for Multicultural Affairs in Transplantation
  • Michigan Health & Hospital Association
  • Donate Life Coalition of Michigan
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